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Daniel Amen: Lessons from Brain Imaging
 
 
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Speech of the Week

Ben Goldacre

On Prescription Drug Bias

delivered September 2012

"In March 2012...some researchers reported in the journal, Nature, how they had tried to replicate 53 different basic science studies looking at potential treatment targets in cancer.  Out of those 53 studies, they were only able to successfully replicate 6; 47 out of those 53 were unreplicable.  And they say in their discussion that this is very likely because freaks get published."

"But it doesn't just happen in the very dry world of preclinical basic science cancer research.  It also happens in the very real, flesh and blood of academic medicine."

"In 1980, some researchers did a study on a drug called Lorcainide and this was an antiarrhythmic drug, a drug that suppresses abnormal heart rhythms.  And the idea was after people have had a heart attack, they're quite likely to have abnormal heart rhythm.  So if we give them a drug that suppresses abnormal heart rhythms, this will increase the chances of them surviving."

"Early on in this development, they did a very small trial, just under a 100 patients; 50 patients got Lorcainide and of those patients 10 died.  Another 50 patients got a dummy placebo sugar pill with no active ingredient and only one of them died.  So they rightly regarded this drug as a failure and its commercial development was stopped.  And because its commercial development was stopped, this trial was never published."

"Unfortunately, over the course of the next 5, 10 years other companies had the same idea about drugs that would prevent arrhythmias in people who've had heart attacks.  These drugs were brought to market.  They were prescribed very widely because heart attacks are a very common thing.  And it took so long for us to find out that these drugs also caused an increased rate of death.  But before we detected that safety signal, over a 100,000 people died unnecessarily in America from the prescription of antiarrhythmic drugs."

Text and Video of Address

American Rhetoric Exclusive: Colombia, Summer 2016 -- A Visual Rhetoric in Still and Moving Images

George W. Bush: The 3 Pillars of Security [Video Added]

George W. Bush: National Day of Prayer and Remembrance Service Address [AndioXE and Entire Video Added]

Jesse Jackson: Jackie Robinson Congressional Gold Medal Award Ceremony Address [w/ Audio and Video]

Barack Obama: Statement on the Flooding in Baton Rouge, Louisiana [w/ AudioXE and Video]

Emperor Akihito: Personal Health and Constitutional Duty Speech to the Nation [w/ AudioXE and Video]

Richard Nixon: 1974 State of the Union Address [w/ Video]

Dr. Tom Frieden: CDC Travel Advisory Statement for South Florida and Q&A Briefing [w/ Audio]

Lyndon Baines Johnson: Howard University Commencement Address [w/ Audio and Video]

Hillary Clinton: 2016 Democratic Presidential Nomination Acceptance [w/ Audio and Video]]

Iraq War Speeches

12/15/11 Secretary of Defense Leon Panetta Marks the End of Operation New Dawn

08/31/10 President's Oval Office Address Announcing End of Operation Iraqi Freedom

2/27/09 President's Address at Camp Lejeune on Ending the War in Iraq

10/12/07 General Ricardo Sanchez's Address to Military Reporters and Editors

9/13/07 President's Address to the Nation on Moving Forward in Iraq

9/10/07 General David Petraeus' Opening Statement to Congress on the Status in Iraq

7/12/07 President's Press Conference on Iraq War

1/10/07 President's Address to the Nation on Troop Increase

9/11/06 President's National Address on Five-Year Anniversary of 9/11

12/18/05 President's National Address in Oval Office

2/4/05 L. Paul Bremer: TD Waterhouse Conference Keynote Address

2/02/05 President's 2005 State of the Union Address

1/30/05 President's Address Following Democratic Election in Iraq

10/4/04 Donald Rumsfeld's Address to the Council on Foreign Relations

4/13/04 President's Prime Time News Conference on Iraq War

4/8/04 Condoleezza Rice: 9/11 Commission Opening Statement

1/20/04 President's 2004 State of the Union Address

12/14/03 President Announces Capture of Saddam Hussein

5/01/03 President Announces End of Combat Ops in Iraq

Ashleigh Banfield: Landon Lecture at Kansas State University

4/13/04 President's Prime Time Press Conference on Iraq War

4/10/03 President and UK Prime Minister Addresses to the Peoples of Iraq

4/03/03 President's Address at Camp Lejeune

3/19/03 Senator Robert Byrd: The Arrogance of Power

3/19/03 President's Address to the Nation: Initial Ops in Iraq

3/17/03 President's Ultimatum to Saddam

2/05/03 Colin Powell's Address to the UN Security Council

1/28/03 President's State of the Union Address

8/26/02 Vice President Cheney's Address to the Veterans of Foreign Wars 103rd National Convention

2/02/02 Paul Wolfowitz's Address at the 38th Verkunde Conference

1/29/02 President's State of the Union Address

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